Ramnik xavier biography of christopher brown

Spatially restricted immune and microbiota-driven adaptation of the gut. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans.

Ramnik Xavier is a core institute member of the Broad Institute of MIT and Harvard, where he serves as director of the Klarman Cell Observatory.

Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut. The treatment-naive microbiome in new-onset Crohn's disease. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course.

Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level. Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.

Ramnik Xavier is the Kurt Isselbacher Professor of Medicine at Harvard Medical School; director of the Center for Computational and Integrative Biology and member of the Department of Missing: christopher brown.

Gut microbiome structure and metabolic activity in inflammatory bowel disease. Atg16L1 TA variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. T helper cell cytokines modulate intestinal stem cell renewal and differentiation. C1orf is a colitis risk gene that regulates stability of epithelial adherens junctions.

Pathway paradigms revealed from the genetics of inflammatory bowel disease. Genetics and pathogenesis of inflammatory bowel disease. U nravelling the pathogenesis of inflammatory bowel disease.